abstract：:Secretory granules of pancreatic β-cells contain high concentrations of Ca2+ ions that are co-released with insulin in the extracellular milieu upon activation of exocytosis. As a consequence, an increase in the extracellular Ca2+ concentration ([Ca2+]ext) in the microenvironment immediately surrounding β-cells should...

journal_title：Cell calcium

authors： Gerbino A,Maiellaro I,Carmone C,Caroppo R,Debellis L,Barile M,Busco G,Colella M

更新日期：2012-05-01 00:00:00

abstract：:The secretion of adrenocorticotrophin (ACTH) from corticotropes is a key component in the endocrine response to stress. The resting potential of corticotropes is set by the basal activities of TWIK-related K(+) (TREK)-1 channel. Corticotrophin-releasing hormone (CRH), the major ACTH secretagogue, closes the background...

journal_title：Cell calcium

authors： Tse A,Lee AK,Tse FW

更新日期：2012-03-01 00:00:00

abstract：:Corticosteroid hormones, which are released in high amounts after stress, easily pass the blood-brain-barrier. In the brain they bind to intracellular receptors which act as transcriptional regulators. These receptors are highly expressed in neurons of the hippocampal formation and the amygdala, areas that play a role...

journal_title：Cell calcium

authors： Joëls M,Karst H

更新日期：2012-03-01 00:00:00

abstract：:Relative to mammals, the neuroendocrine control of pituitary growth hormone (GH) secretion and synthesis in teleost fish involves numerous stimulatory and inhibitory regulators, many of which are delivered to the somatotrophs via direct innervation. Among teleosts, how multifactorial regulation of somatotroph function...

journal_title：Cell calcium

authors： Chang JP,Habibi HR,Yu Y,Moussavi M,Grey CL,Pemberton JG

更新日期：2012-03-01 00:00:00

abstract：:The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exocytosis. Here we di...

journal_title：Cell calcium

authors： Rorsman P,Braun M,Zhang Q

更新日期：2012-03-01 00:00:00

abstract：:The high capacity, low affinity Ca(2+) storage protein chromogranins are marker proteins of secretory granules that contain the most Ca(2+) in secretory cells. Along with the abundantly expressed chromogranins, the IP(3)R/Ca(2+) channels, the major intracellular Ca(2+) channels, are also expressed in secretory granule...

journal_title：Cell calcium

authors： Yoo SH,Hur YS

更新日期：2012-03-01 00:00:00

abstract：:While genetically encoded Ca(2+) indicators (GECIs) allow Ca(2+) imaging in model organisms, the gene expression is often under the control of a single promoter that may drive expression beyond, the cell types of interest. To enable more cell-type specific targeting, GECIs can be brought under the, control of the inte...

journal_title：Cell calcium

authors： Wong SS,Kotera I,Mills E,Suzuki H,Truong K

更新日期：2012-01-01 00:00:00

abstract：:There is controversy as to whether TRP channels participate in mediating store-operated current (I(SOC)) and store-operated Ca(2+) entry (SOCE). Our recent study has demonstrated that TRPC1 forms heteromeric channels with TRPV4 in vascular endothelial cells and that Ca(2+) store depletion enhances the vesicle traffick...

journal_title：Cell calcium

authors： Ma X,Cheng KT,Wong CO,O'Neil RG,Birnbaumer L,Ambudkar IS,Yao X

更新日期：2011-12-01 00:00:00

abstract：:Smooth muscle contraction is regulated by changes in cytosolic Ca(2+) concentration ([Ca(2+)](i)). In response to stimulation, Ca(2+) increase in a single cell can propagate to neighbouring cells through gap junctions, as intercellular Ca(2+) waves. To investigate the mechanisms underlying Ca(2+) wave propagation betw...

journal_title：Cell calcium

authors： Halidi N,Boittin FX,Bény JL,Meister JJ

更新日期：2011-11-01 00:00:00

abstract：:Mast cells are considered the primary initiators of allergic diseases as a consequence of the release of multiple inflammatory mediators on activation. Although predominately activated through antigen-mediated aggregation of IgE-occupied-FcɛRI, they can also be induced to release mediators by other receptors and envir...

journal_title：Cell calcium

authors： Medic N,Desai A,Komarow H,Burch LH,Bandara G,Beaven MA,Metcalfe DD,Gilfillan AM

更新日期：2011-11-01 00:00:00

abstract：:Dendritic Ca2+ plays an important role not only in synaptic integration and synaptic plasticity, but also in dendritic excitability in midbrain dopamine neurons. However, the functional organization of dendritic Ca2+ signals in the dopamine neurons remains largely unknown. We therefore investigated dendritic Ca2+ sign...

journal_title：Cell calcium

authors： Jang M,Jang JY,Kim SH,Uhm KB,Kang YK,Kim HJ,Chung S,Park MK

更新日期：2011-10-01 00:00:00

abstract：:The release of Ca2+ ions from the sarcoplasmic reticulum through ryanodine receptor calcium release channels represents the critical step linking electrical excitation to muscular contraction in the heart and skeletal muscle (excitation-contraction coupling). Two small Ca2+ binding proteins, S100A1 and calmodulin, hav...

journal_title：Cell calcium

authors： Prosser BL,Hernández-Ochoa EO,Schneider MF

更新日期：2011-10-01 00:00:00

abstract：:A variety of stimuli utilize an increase of cytosolic free Ca(2+) concentration as a second messenger to transmit signals, through Ca(2+) release from the endoplasmic reticulum or opening of plasma membrane Ca(2+) channels. Mitochondria contribute to the tight spatiotemporal control of this process by accumulating Ca(...

journal_title：Cell calcium

authors： Rasola A,Bernardi P

更新日期：2011-09-01 00:00:00

abstract：:Ca(2+) is known as a universal messenger mediating a wide variety of cellular processes, including cell death. In fact, this ion has been proposed as the 'cell death master', not only at the intracellular but also at the intercellular level. The most direct form of intercellular spread of cell death is mediated by gap...

journal_title：Cell calcium

authors： Decrock E,Vinken M,Bol M,D'Herde K,Rogiers V,Vandenabeele P,Krysko DV,Bultynck G,Leybaert L

更新日期：2011-09-01 00:00:00

abstract：:The Bcl-2 protein, best known for its ability to inhibit apoptosis, interacts with the inositol 1,4,5-trisphosphate receptor (IP(3)R) Ca(2+) channel to regulate IP(3)-mediated Ca(2+) release from the endoplasmic reticulum. This review summarizes the current state of knowledge regarding the interaction of Bcl-2, and al...

journal_title：Cell calcium

authors： Distelhorst CW,Bootman MD

更新日期：2011-09-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective death of motor neurons. Mutations in Cu/Zn superoxide dismutase-1 (SOD1) cause familial ALS but the molecular mechanisms whereby these mutations induce motor neuron death remain controversial. Here, we show that stable overex...

journal_title：Cell calcium

authors： Coussee E,De Smet P,Bogaert E,Elens I,Van Damme P,Willems P,Koopman W,Van Den Bosch L,Callewaert G

更新日期：2011-04-01 00:00:00

abstract：:Amyloid beta (Aβ) oligomers accumulate in the brain tissue of Alzheimer disease patients and are related to disease pathogenesis. The precise mechanisms by which Aβ oligomers cause neurotoxicity remain unknown. We recently reported that Aβ oligomers cause intracellular Ca(2+) overload and neuronal death that can be pr...

journal_title：Cell calcium

authors： Texidó L,Martín-Satué M,Alberdi E,Solsona C,Matute C

更新日期：2011-03-01 00:00:00

abstract：:Cyclic AMP regulates the late step of Ca²+-dependent exocytosis in many secretory cells through two major mechanisms: a protein kinase A-dependent and a cAMP-GEF/Epac-dependent pathway. We designed a protocol to characterize the role of these two cAMP-dependent pathways on the Ca²+ sensitivity and kinetics of regulate...

journal_title：Cell calcium

authors： Skelin M,Rupnik M

更新日期：2011-02-01 00:00:00

abstract：:TRPV6 belongs to the vanilloid family of the transient receptor potential channel (TRP) superfamily. This calcium-selective channel is highly expressed in the duodenum and the placenta, being responsible for calcium absorption in the body and fetus. Previous observations have suggested that TRPV6 is not only permeable...

journal_title：Cell calcium

authors： Kovacs G,Danko T,Bergeron MJ,Balazs B,Suzuki Y,Zsembery A,Hediger MA

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this study was to invent an extracellular inhibitor selective for the plasma membrane Ca(2+) pump(s) (PMCA) isoform 1. PMCA extrude Ca(2+) from cells during signalling and homeostasis. PMCA isoforms are encoded by 4 genes (PMCA1-4). Pig coronary artery endothelium and smooth muscle express the genes PMC...

journal_title：Cell calcium

authors： Szewczyk MM,Pande J,Akolkar G,Grover AK

更新日期：2010-12-01 00:00:00

abstract：:Changes in the concentration and spatial distribution of Ca(2+) ions in the cytoplasm constitute a ubiquitous intracellular signaling module in cellular physiology. With the advent of Ca(2+) dyes that allow direct visualization of Ca(2+) transients, combined with powerful experimental tools such as electrophysiologica...

journal_title：Cell calcium

authors： Machaca K

更新日期：2010-11-01 00:00:00

abstract：:Dopamine is one of the key neurotransmitters in the central nervous system and plays an important role in physiological processes, as well as in the development of many diseases. Here we report a receptor-independent signalling pathway induced by dopamine in CNS neurons. In cultured neurons from midbrain, cortex and h...

journal_title：Cell calcium

authors： Vaarmann A,Gandhi S,Gourine AV,Abramov AY

更新日期：2010-08-01 00:00:00

abstract：:NAADP is a potent regulator of cytosolic calcium levels. Much evidence suggests that NAADP activates a novel channel located on an acidic (lysosomal-like) calcium store, the mobilisation of which results in further calcium release from the endoplasmic reticulum. Here, we discuss the recent identification of a family o...

journal_title：Cell calcium

authors： Patel S,Marchant JS,Brailoiu E

更新日期：2010-06-01 00:00:00

abstract：:In skeletal muscle excitation-contraction (EC) coupling the sarcolemmal L-type Ca(2+) channel or 1,4-dihydropyridine receptor (DHPR) transduces the membrane depolarization signal to the sarcoplasmic Ca(2+) release channel RyR1 via protein-protein interaction. While it is evident that the pore-forming and voltage-sensi...

journal_title：Cell calcium

authors： Dayal A,Schredelseker J,Franzini-Armstrong C,Grabner M

更新日期：2010-06-01 00:00:00

abstract：:Great insight has been gained into the structure and function of the inositol 1,4,5 trisphosphate receptor (InsP(3)R) by studies employing mutagenesis of the cDNA encoding the receptor. Notably, early studies using this approach defined the key constituents required for InsP(3) binding in the N-terminus and the membra...

journal_title：Cell calcium

authors： Yule DI,Betzenhauser MJ,Joseph SK

更新日期：2010-06-01 00:00:00

abstract：:Calcium-activated potassium channels are important in a variety of smooth muscles, contributing to excitability and contractility. In the myometrium previous work has focussed on the large conductance channels (BK), and the role of small conductance channels (SK) has received scant attention, despite the finding that ...

journal_title：Cell calcium

authors： Noble K,Floyd R,Shmygol A,Shmygol A,Mobasheri A,Wray S

更新日期：2010-01-01 00:00:00

abstract：:Sarcoplasmic reticulum contains the internal Ca(2+) store in smooth muscle cells and its lumen appears to be a continuum that lacks diffusion barriers. Accordingly, the free luminal Ca(2+) level is the same all throughout the SR; however, whether the Ca(2+) buffer capacity is the same in all the SR is unknown. We have...

journal_title：Cell calcium

authors： Dagnino-Acosta A,Guerrero-Hernández A

更新日期：2009-09-01 00:00:00

abstract：:In the cochlea, cell damage triggers intercellular Ca2+ waves that propagate through the glial-like supporting cells that surround receptor hair cells. These Ca2+ waves are thought to convey information about sensory hair cell-damage to the surrounding supporting cells within the cochlear epithelium. Mitochondria are ...

journal_title：Cell calcium

authors： Mann ZF,Duchen MR,Gale JE

更新日期：2009-08-01 00:00:00

abstract：:The regulation of intracellular Ca(2+) signalling by phosphorylation processes remains poorly defined, particularly with regards to tyrosine phosphorylation. Evidence from non-excitable cells implicates tyrosine phosphorylation in the activation of so-called store-operated Ca(2+) channels (SOCCs), but their involvemen...

journal_title：Cell calcium

authors： Koss DJ,Riedel G,Platt B

更新日期：2009-07-01 00:00:00

abstract：:TRPC channels are a subset of the transient receptor potential (TRP) proteins widely expressed in mammalian cells. They are thought to be primarily involved in determining calcium or sodium entry and have broad-ranging functions that include regulation of cell proliferation, motility and contraction. The channels do n...

journal_title：Cell calcium

authors： Beech DJ,Bahnasi YM,Dedman AM,Al-Shawaf E

更新日期：2009-06-01 00:00:00

abstract：:This work shows, for the first time, a properly metabolically regulated squid nerve Na(+)/Ca(2+) exchanger (NCXSQ1) heterologous expressed in Saccharomyces cerevisiae. The exchanger was fused to the enhanced green fluorescence protein (eGFP) on its C-terminus and had two tags, a Strep-tag II and 6 histidines, added to...

journal_title：Cell calcium

authors： Raimunda D,Bollo M,Beaugé L,Berberián G

更新日期：2009-05-01 00:00:00

abstract：:The store-operated, calcium release-activated calcium current I(CRAC) is activated by the depletion of inositol 1,4,5-trisphosphate (IP(3))-sensitive stores. The significantly different dose-response relationships of IP(3)-mediated Ca(2+) release and CRAC channel activation indicate that I(CRAC) is activated by a func...

journal_title：Cell calcium

authors： Peinelt C,Beck A,Monteilh-Zoller MK,Penner R,Fleig A

更新日期：2009-04-01 00:00:00

abstract：:Mitochondrial Ca(2+) activates many processes, from mitochondrial metabolism to opening of the permeability transition pore (PTP) and apoptosis. However, there is considerable controversy regarding the free mitochondrial [Ca(2+)] ([Ca(2+)](M)) levels that can be attained during cell activation or even in mitochondrial...

journal_title：Cell calcium

authors： Vay L,Hernández-SanMiguel E,Lobatón CD,Moreno A,Montero M,Alvarez J

更新日期：2009-03-01 00:00:00

abstract：:TRPA1, a Ca(2+)-permeable cation channel that is expressed in sensory neurones, is involved in the perception of chemical irritants and mechanical hyperalgesia. TRPA1 is activated by either covalent or reversible binding of various chemical compounds, including allylisothiocyanate or acrolein, and is further sensitise...

journal_title：Cell calcium

authors： Hill K,Schaefer M

更新日期：2009-02-01 00:00:00

abstract：:Ryanodine receptors plays a crucial role in skeletal muscle excitation-contraction coupling by releasing calcium ions required for muscle contraction from the sarcoplasmic reticulum. At least three phenotypes associated with more than 100 RYR1 mutations have been identified; in order to elucidate possible pathophysiol...

journal_title：Cell calcium

authors： Ghassemi F,Vukcevic M,Xu L,Zhou H,Meissner G,Muntoni F,Jungbluth H,Zorzato F,Treves S

更新日期：2009-02-01 00:00:00

abstract：:In murine ventricular myocytes, activation of mechanosensitive ion channels (MSCs) includes activation of non-selective cation currents and deactivation of inwardly rectifying potassium currents. Using pharmacological inhibitors and knockout models, we analyzed signaling steps that are critical to transduce the mechan...

journal_title：Cell calcium

authors： Dyachenko V,Rueckschloss U,Isenberg G

更新日期：2009-01-01 00:00:00

abstract：:T-type Ca(2+) channel family includes three subunits Ca(V)3.1, Ca(V)3.2 and Ca(V)3.3 and have been shown to control burst firing and intracellular Ca(2+) concentration ([Ca(2+)](i)) in neurons. Here, we investigated whether Ca(V)3.1 channels could generate a pacemaker current and contribute to cell excitability. Ca(V)...

journal_title：Cell calcium

authors： Chevalier M,Mironneau C,Macrez N,Quignard JF

更新日期：2008-12-01 00:00:00

abstract：:The control of calcium homeostasis is essential for cell survival and is of crucial importance for several physiological functions. The discovery of the epithelial calcium channel Transient Receptor Potential Vaniloid (TRPV6) in intestine has uncovered important Ca(2+) absorptive pathways involved in the regulation of...

journal_title：Cell calcium

authors： Irnaten M,Blanchard-Gutton N,Harvey BJ

更新日期：2008-11-01 00:00:00

abstract：:The L-type Ca2+ channel (Ca(v)1.2) is the main pathway for trans-sarcolemmal (SL) Ca2+ influx in cardiac myocytes. To maintain Ca2+ homeostasis, chronic SL Ca(2+)-influx must be matched by chronic SL efflux. In this study we tested the hypothesis that chronic downregulation of SL Ca2+ entry regulates SL extrusion. We ...

journal_title：Cell calcium

authors： Lester WC,Schroder EA,Burgess DE,Yozwiak D,Andres DA,Satin J

更新日期：2008-10-01 00:00:00

abstract：:Cell survival is promoted by the oncoprotein Bcl-2. Previous studies have established that one of the pro-survival actions of Bcl-2 is to reduce cellular fluxes of Ca2+ within cells. In particular, Bcl-2 has been demonstrated to inhibit the release of Ca2+ from the endoplasmic reticulum. However, the mechanism by whic...

journal_title：Cell calcium

authors： Hanson CJ,Bootman MD,Distelhorst CW,Wojcikiewicz RJ,Roderick HL

更新日期：2008-09-01 00:00:00